For virologically suppressed adult patients with HIV-1. See Full Indication.
JULUCA | Dosing & Drug Interactions
Dosing Recommendations for JULUCA
Pregnancy testing is recommended before initiation of JULUCA in individuals of childbearing potential.
Dosing and administration
The recommended dose of JULUCA is 1 tablet taken orally once daily with a meal. |
If JULUCA is coadministered with rifabutin, an additional 25-mg tablet of rilpivirine should be taken with JULUCA once daily with a meal for the duration of the rifabutin administration. |
Drug Interactions for JULUCA
Established and Other Potentially Significant Drug Interactions
AGENT | RECOMMENDATIONS |
Antacids (eg, aluminum or magnesium hydroxide, calcium carbonate) | Administer JULUCA 4 hours before or 6 hours after taking antacids. |
Antiarrhythmic: Dofetilide |
Coadministration is contraindicated with JULUCA. |
Anticonvulsants: Carbamazepine Oxcarbazepine Phenobarbital Phenytoin |
Coadministration is contraindicated with JULUCA due to decreased rilpivirine concentrations. |
Antidiabetic: Metformin |
Refer to the prescribing information for metformin for assessing the benefit and risk of concomitant use of JULUCA and metformin. |
Antimycobacterials: Rifampin Rifapentine |
Coadministration is contraindicated with JULUCA due to decreased rilpivirine concentrations. |
Antimycobacterial: Rifabutin |
An additional rilpivirine 25-mg tablet should be taken with JULUCA once daily with a meal when rifabutin is coadministered. |
Glucocorticoid (systemic): Dexamethasone (more than a single-dose treatment) |
Coadministration is contraindicated with JULUCA due to decreased rilpivirine concentrations. |
H2-receptor antagonists: Famotidine Cimetidine Nizatidine Ranitidine |
JULUCA should only be administered at least 4 hours before or 12 hours after taking H2-receptor antagonists. |
Herbal product: St John’s wort (Hypericum perforatum) |
Coadministration is contraindicated with JULUCA due to decreased rilpivirine concentrations. |
Macrolide or ketolide antibiotics: Clarithromycin Erythromycin Telithromycin |
Where possible, consider alternatives, such as azithromycin. |
Medications containing polyvalent cations (eg, Mg or Al): Cation-containing products or laxatives Sucralfate Buffered medications |
Administer JULUCA 4 hours before or 6 hours after taking products containing polyvalent cations. |
Narcotic analgesic: Methadone |
No dose adjustments are required when starting coadministration of methadone with JULUCA. However, clinical monitoring is recommended as methadone maintenance therapy may need to be adjusted in some patients. |
Oral calcium and iron supplements, including multivitamins containing calcium or iron (nonantacid) | Administer JULUCA and supplements containing calcium or iron together with a meal or take JULUCA 4 hours before or 6 hours after taking these supplements. |
Potassium channel blocker: |
Elevated levels of dalfampridine increase the risk of seizures. The potential benefits of taking dalfampridine concurrently with JULUCA should be considered against the risk of seizures in these patients. |
Proton pump inhibitors: eg, Esomeprazole Lansoprazole Omeprazole Pantoprazole Rabeprazole |
Coadministration is contraindicated with JULUCA due to decreased rilpivirine concentrations. |
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