For virologically suppressed adult patients with HIV-1

Dosing Recommendations for JULUCA

 

Perform pregnancy testing before initiation of JULUCA in adolescents and adults of childbearing potential.

Dosing and administration

The recommended dose of JULUCA is 1 tablet taken orally once daily with a meal.
If JULUCA is coadministered with rifabutin, an additional 25-mg tablet of rilpivirine should be taken with JULUCA once daily with a meal for the duration of the rifabutin administration.

For virologically suppressed adult patients with HIV-1

Drug Interactions for JULUCA

 

Established and Other Potentially Significant Drug Interactions

AGENT
RECOMMENDATIONS
Antacids (eg, aluminum or magnesium hydroxide, calcium carbonate)

Administer JULUCA 4 hours before or 6 hours after taking antacids.
Antiarrhythmic:
Dofetilide
Coadministration is contraindicated with JULUCA.
Anticonvulsants:
Carbamazepine
Oxcarbazepine
Phenobarbital
Phenytoin
Coadministration is contraindicated with JULUCA due to decreased rilpivirine concentrations.
Antidiabetic:
Metformin
With concomitant use, limit the total daily dose of metformin to 1000 mg either when starting metformin or JULUCA. When starting or stopping JULUCA, the metformin dose may require an adjustment. Monitoring of blood glucose when initiating concomitant use and after withdrawal of JULUCA is recommended.
Antimycobacterials:
Rifampin
Rifapentine
Coadministration is contraindicated with JULUCA due to decreased rilpivirine concentrations.
Antimycobacterial:
Rifabutin
An additional rilpivirine 25-mg tablet should be taken with JULUCA once daily with a meal when rifabutin is coadministered.
Glucocorticoid (systemic):
Dexamethasone (more than a single-dose treatment)
Coadministration is contraindicated with JULUCA due to decreased rilpivirine concentrations.
H2-Receptor Antagonists:
Famotidine
Cimetidine
Nizatidine
Ranitidine
JULUCA should only be administered at least 4 hours before or 12 hours after taking H2-receptor antagonists.
Herbal Product:
St John’s wort (Hypericum perforatum)
Coadministration is contraindicated with JULUCA due to decreased rilpivirine concentrations.
Macrolide or ketolide antibiotics:
Clarithromycin
Erythromycin
Telithromycin
Where possible, consider alternatives, such as azithromycin.
Medications containing polyvalent cations (eg, Mg or Al):
Cation-containing products or laxatives
Sucralfate
Buffered medications
Administer JULUCA 4 hours before or 6 hours after taking products containing polyvalent cations.
Narcotic analgesic:
Methadone
No dose adjustments are required when starting coadministration of methadone with JULUCA. However, clinical monitoring is recommended as methadone maintenance therapy may need to be adjusted in some patients.
Oral calcium and iron supplements, including multivitamins containing calcium or iron (nonantacid)
Administer JULUCA and supplements containing calcium or iron together with a meal or take JULUCA 4 hours before or 6 hours after taking these supplements.
Proton Pump Inhibitors:
eg, Esomeprazole
Lansoprazole
Omeprazole
Pantoprazole
Rabeprazole
Coadministration is contraindicated with JULUCA due to decreased rilpivirine concentrations.