Early Antiretroviral Therapy (ART):
Zidovudine (AZT) is the first medication approved for the treatment of HIV-11
Combinations of certain ARTs are effective regimens, but may require multiple pills taken more than once per day1
Once Daily STRs:
Single-tablet, 3-drug regimens achieve virologic suppression with 1 pill taken once per day1
A Complete 2-drug Regimen:
The only 2-drug regimen indicated for virologically suppressed adult patients with HIV-1
HAART=highly active antiretroviral therapy; STRs=single-tablet regimens.
Many Patients Could Be on ART for 40 or More Years2
How can limiting the number of medications in an HIV-1 regimen impact a patient over the length of treatment?
The pairing of dolutegravir and rilpivirine inhibits the viral life cycle at 2 separate sites, like traditional 3-drug regimens
Mechanism of Action for 2-Drug Regimen JULUCA
- HIV/AIDS history of approvals. https://www.fda.gov/forpatients/illness/hivaids/history/default.htm. Accessed June 11, 2018.
- Antiretroviral Therapy Cohort Collaboration. Survival of HIV-positive patients starting antiretroviral therapy between 1996 and 2013: a collaborative analysis of cohort studies. Lancet HIV. 2017;4(8):e349-e356.