Milestones in the Treatment of HIV-1

 

1987

Early Antiretroviral Therapy (ART):

Zidovudine (AZT) is the first medication approved for the treatment of HIV-11

 

 

1996

HAART:

Combinations of certain ARTs are effective regimens, but may require multiple pills taken more than once per day1

 

2006

Once Daily STRs:

Single-tablet, 3-drug regimens achieve virologic suppression with 1 pill taken once per day1

2017

A Complete 2-drug Regimen:

The only 2-drug regimen indicated for virologically suppressed adult patients with HIV-1

HAART=highly active antiretroviral therapy; STRs=single-tablet regimens.

 

 

 

 

Many Patients Could Be on ART for 40 or More Years2

How can limiting the number of medications in an HIV-1 regimen impact a patient over the length of treatment?

For virologically suppressed adult patients with HIV-1

An Innovative Pairing With Dolutegravir

The pairing of dolutegravir and rilpivirine inhibits the viral life cycle at 2 separate sites, like traditional 3-drug regimens

Mechanism of Action for 2-Drug Regimen JULUCA

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References:

  1. HIV/AIDS history of approvals. https://www.fda.gov/forpatients/illness/hivaids/history/default.htm. Accessed June 11, 2018.
  2. Antiretroviral Therapy Cohort Collaboration. Survival of HIV-positive patients starting antiretroviral therapy between 1996 and 2013: a collaborative analysis of cohort studies. Lancet HIV. 2017;4(8):e349-e356.